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The Research Project Grant (R01) is an award made to support a discrete, specified, circumscribed project to be performed by PI's in areas representing the investigators' specific interests and competencies, based on the mission of NIH. The R01 is the original and historically the oldest grant mechanism used by NIH to support health-related research and development.

R01 deadlines follow the annual standard due dates of 5pm local time on February 5, June 5, and October 5.

Applications are generally awarded for 1 - 5 budget periods, each normally 12 months in duration.

Applications for an R01 are not limited in dollars but need to reflect the actual needs of the proposed project. Modular budgets are most prevalent with modules of $25,000, up to the modular limit of $250,000. U.S. applicants requesting more than $250,000 in annual direct costs must complete and submit detailed budget requests using the Research & Related Budget. Applicants requesting $500,000 or more in direct costs in any year (excluding consortium F&A) must contact NIH program staff in advance. More details can be found in proposal elements.


Any qualified PI with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with the University to submit a proposal.

NIH encourages new investigators and has two special investigator categories. A "new investigator" is an applicant who hasn't received an R01 (or similar) grant from NIH, and an "early stage investigator" is someone who, in addition, is no more than 10 years past a terminal degree. You can only use your new or early-stage investigator status once so use it wisely. Read more on New and Early-Stage Investigator policies.

If you are eligible to submit a proposal, please see the links to the right and continue reading about:

  1. NIH Institutes and Centers (under construction)
  2. Proposal Elements (under construction)
  3. Merit Review Criteria (under construction)
  4. Proposal Submission (under construction)
Last Updated: 12/1/22